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Neoplastic meningitis: metastases to the leptomeninges and cerebrospinal fluid 

Neoplastic meningitis: metastases to the leptomeninges and cerebrospinal fluid
Chapter:
Neoplastic meningitis: metastases to the leptomeninges and cerebrospinal fluid
Author(s):

Marc C. Chamberlain

, Stephanie E. Combs

, and Soichiro Shibui

DOI:
10.1093/med/9780199651870.003.0021
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date: 30 May 2020

Carcinomatous meningitis or meningeal carcinomatosis is a term that defines leptomeningeal metastases arising as a result of metastases from systemic solid cancers. Similarly, lymphomatous and leukaemic meningitis result from cerebrospinal fluid dissemination of lymphoma or leukaemia. All three entities are commonly referred to as neoplastic meningitis or leptomeningeal metastases due to involvement of both the cerebrospinal fluid compartment as well as the leptomeninges comprised of the pia and arachnoid. Treatment options are limited for these neurological complications and outcomes are generally poor. New therapeutic strategies are desperately needed as more cancer patients survive longer and are at increased risk for neoplastic meningitis.

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