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Metastatic tumours: spinal cord, plexus, and peripheral nerve 

Metastatic tumours: spinal cord, plexus, and peripheral nerve
Metastatic tumours: spinal cord, plexus, and peripheral nerve

David Schiff

, Jonathan Sherman

, and Paul D. Brown

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date: 27 February 2021

Systemic cancers produce substantial neurological morbidity when they spread to the spinal epidural space, producing epidural spinal cord compression—a neurological emergency. Less often, metastases spread directly to spinal cord parenchyma to manifest as intramedullary spinal cord metastasis or result in peripheral nerve dysfunction via compression of the brachial, lumbosacral, or, rarely, the cervical plexus. This chapter reviews the clinical manifestations and risk factors for development of these entities, the diagnostic approach, management options including the role of surgery, radiation (including stereotactic body radiation therapy), and chemotherapy, as well as the neurological prognosis.

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