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Metastatic brain tumours 

Metastatic brain tumours
Chapter:
Metastatic brain tumours
Author(s):

Matthias Preusser

, Gabriele Schackert

, and Brigitta G. Baumert

DOI:
10.1093/med/9780199651870.003.0019
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date: 30 October 2020

Brain metastasis is a common clinical challenge in cancer patients, particularly those with lung cancer, breast cancer, and melanoma. The prognosis is poor, with median overall survival times measured in months for most patient populations. Established treatments include neurosurgical resection, radiotherapy (including stereotactic radiosurgery and stereotactic radiotherapy, whole-brain radiotherapy, and new radiation techniques), and supportive care measures. Recently, more and more targeted therapies such as EGFR inhibitors, HER2 antagonists, BRAF inhibitors, ALK inhibitors, and immune checkpoint inhibitors are demonstrating some efficacy in brain metastasis patients and should be considered in the clinical setting.

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