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Germ cell tumours 

Germ cell tumours
Chapter:
Germ cell tumours
Author(s):

Claire Alapetite

, Takaaki Yanagisawa

, and Ryo Nishikawa

DOI:
10.1093/med/9780199651870.003.0014
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date: 30 May 2020

Central nervous system germ cell tumours are mysterious tumours, which are common in young male adults in eastern Asia, and include germinoma, mature and immature teratoma, teratoma with malignant transformation, yolk sac tumour, embryonal carcinoma, choriocarcinoma, and mixed tumours of these components. The aetiological mechanism why they mostly develop in the pineal and neurohypophyseal region is still unknown. Their treatment is also a challenge; surgery is demanding, and sometimes biopsy would be preferred. Radiotherapy is effective, but its dose and field would be better reduced for young adults and children. Chemotherapy is effective but not enough for especially non-germinomatous tumours. This chapter presents a comprehensive discussion about those challenging diseases.

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