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Once more unto the breach: the role of the damaged bronchial epithelium in asthma 

Once more unto the breach: the role of the damaged bronchial epithelium in asthma
Chapter:
Once more unto the breach: the role of the damaged bronchial epithelium in asthma
Author(s):

Karl Staples

and Ratko Djukanovic

DOI:
10.1093/med/9780199651559.003.0056
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date: 18 November 2019

Addressing the hypothesis that epithelial damage is related to bronchial hyperreactivity, Laitinen et al. measured bronchial reactivity to inhaled histamine and took biopsies from three levels of the airway mucosa of eight adult patients with mild to severe asthma and one control subject, preparing electron micrographs from the specimens. The results showed that asthma patients can have profound airway epithelium destruction at all levels of the airway, with ciliated cells the most destroyed cell type. The authors suggest that epithelial damage is caused by asthma itself rather than medication.

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