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Delayed hypersensitivity to pollen allergens 

Delayed hypersensitivity to pollen allergens
Delayed hypersensitivity to pollen allergens

Tom Platts-Mills

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date: 24 June 2021

Pollen-induced lymphocyte transformation in hay-fever subjects with clinical immediate hypersensitivity reflects the presence of a sensitised thymus-dependent cell population, which also gives rise to positive macrophage and leucocyte migration-inhibition tests in vitro and delayed-type skin tests in vivo. It is postulated that the thymus-dependent (T-) lymphocytes cooperate in the production of IgE antibody by B-lymphocytes of the plasma-cell series. Lymphocyte transformation per se should still be regarded as a manifestation of cell-mediated (delayed) hypersensitivity in vitro, whatever the apparent clinical correlations may be.

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