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The discovery of IgE 

The discovery of IgE
Chapter:
The discovery of IgE
Author(s):

Sami L Bahna

DOI:
10.1093/med/9780199651559.003.0033
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date: 26 June 2019

. . . accumulated evidence has indicated that human reaginic antibodies are associated with γ‎E-globulin. . . . Since the major protein components in reagin-rich fractions so far studied were γ‎G- and/or γ‎A-globulin, further purification of γ‎E-globulin in the fractions was attempted to study the relationship between it and reaginic activity, with use of purified ragweed allergen. Although the protein has not been isolated, reagin-rich preparations were obtained in which the antibody against the allergen was associated with γ‎E-globulin alone.

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