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Identification of slow-reacting substance 

Identification of slow-reacting substance
Chapter:
Identification of slow-reacting substance
Author(s):

Sven-Erik Dahlén

DOI:
10.1093/med/9780199651559.003.0021
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date: 22 July 2019

In recent experiments carried out in this laboratory evidence has been brought forward . . . that the contraction of smooth muscle caused by different venoms are [caused] by a ‘slow-reacting smooth muscle-stimulating substance [SRS]’ which may largely determine the nature of the responses. Bartosch, Feldberg and Nagal (1932) have shown that the injection of the anaphylactic antigen into the perfused lung of the sensitized guinea-pig caused the liberation of histamine. Our experiments show in addition that a substance which in its action on the isolated jejunum of the guinea pig resembles that formed by the action of snake venoms on egg yolk or perfused tissues appears in the outflowing perfusate from the lung after the anaphylactic response. This substance may be identical with that formed by the action of snake venom, though we have no proof that this is the case. For convenience, however, we shall refer to it as SRS.

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