Show Summary Details
Page of

Identification of slow-reacting substance 

Identification of slow-reacting substance
Identification of slow-reacting substance

Sven-Erik Dahlén

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 02 March 2021

In recent experiments carried out in this laboratory evidence has been brought forward . . . that the contraction of smooth muscle caused by different venoms are [caused] by a ‘slow-reacting smooth muscle-stimulating substance [SRS]’ which may largely determine the nature of the responses. Bartosch, Feldberg and Nagal (1932) have shown that the injection of the anaphylactic antigen into the perfused lung of the sensitized guinea-pig caused the liberation of histamine. Our experiments show in addition that a substance which in its action on the isolated jejunum of the guinea pig resembles that formed by the action of snake venoms on egg yolk or perfused tissues appears in the outflowing perfusate from the lung after the anaphylactic response. This substance may be identical with that formed by the action of snake venom, though we have no proof that this is the case. For convenience, however, we shall refer to it as SRS.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.