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Celebrating the case study: Schloss’ description of atopic dermatitis 

Celebrating the case study: Schloss’ description of atopic dermatitis
Celebrating the case study: Schloss’ description of atopic dermatitis

Torsten Zuberbier

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date: 27 January 2021

The idiosyncrasy of certain individuals to common foods has been recognized for many years, but until recently our knowledge has depended mainly on isolated clinical observations, and the essential causes of the condition have remained obscure. Through the courtesy of Dr. Eli Long of this city [New York] I have had the opportunity to investigate a case of pronounced idiosyncrasy to eggs, almonds and oats in a child 8 years old, the data from which furnish the basis of this communication . . . the patient’s marked idiosyncrasy to egg was, to say the least, a great inconvenience. A vast amount of care was required in the preparation and supervision of his food and a number of palatable and nutritious food preparations were excluded from his dietary . . . At the very outset it was necessary to revise some test other than actual feeding by which the toxic substances could be identified . . . Treatment was begun Oct. 28, 1911, by the administration of 2 mg. of ovomucoid in capsules three times a day. The dose was increased at first gradually and then more rapidly. At first the quantity was increased at the rate of 2 mg. a day and on November 19 the daily increase was raised to 6 mg. Subsequently the daily increase was as follows: from November 26 to December 5, 12 mg.; from December 5 to December 14, 24 mg.; from December 14 to December 23, 48 mg.; from December 23 to January 1, 78 mg.; from January 1 to January 14, 190 mg.; from January 14, 380 mg. Toward the end of immunization the patient was taking over 7 mg. of ovomucoid a day . . . It is a pleasant duty to express my thanks to the parents of the patient not only for their patience and cooperation during ten months of tedious experimentation, but also for a number of valuable observations.

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