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Research in organ donors: future directions 

Research in organ donors: future directions
Chapter:
Research in organ donors: future directions
Author(s):

Claus Niemann

and Andrea Olmos

DOI:
10.1093/med/9780199651429.003.0009
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date: 19 August 2019

The disparity between the demand for donor organs and supply of organs for transplantation is significant and will likely continue to grow in the coming years. Maximizing the number of transplantable organs from the deceased donor pool via novel donor management strategies is likely the best method for increasing the number of organs available for transplantation, yet deceased donor management is one of the most neglected areas in transplantation medicine and research. Multiple studies have demonstrated that aggressive donor management protocols increase the quantity and quality of organs available for transplantation; however, only a handful of these are intervention trials. Several factors create barriers to conducting randomized prospective studies in deceased organ donors, including the lack of an established research infrastructure. Ethical and regulatory challenges surrounding informed consent for the deceased donor and potential organ recipients are also substantial obstacles to conducting clinical trials. These and other obstacles must be addressed in order to advance research efforts in transplant medicine and bridge the gap between organ supply and demand.

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