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Transfusion medicine and organ transplantation 

Transfusion medicine and organ transplantation
Chapter:
Transfusion medicine and organ transplantation
Author(s):

Richard Charlewood

and Kerry Gunn

DOI:
10.1093/med/9780199651429.003.0036
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date: 17 August 2019

Transfusion medicine is an essential component of organ transplantation and has itself been described as a mini-transplant of viable cells into the recipient. Like organ transplantation, transfusion is associated with several important complications. These include alloimmunization, viral and bacterialinfection, transfusion-associated cardiac overload, organ dysfunction possibly linked to blood component age, and transfusion-related acute lung injury. Organ transplantation has its own specific issues in ABO-incompatible organs and passenger lymphocyte syndrome. Preparation of the patient prior to surgery, as well as restrictive use of transfusion, will reduce these risks, while providing haematological and haemostatic support. Discussions on fractionated products versus fresh components, massive bleeding, and hypothermia in the presence of cold agglutinins are also presented in this chapter.

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