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Paediatric intestinal and multivisceral transplantation: indications, selection, and perioperative management 

Paediatric intestinal and multivisceral transplantation: indications, selection, and perioperative management
Chapter:
Paediatric intestinal and multivisceral transplantation: indications, selection, and perioperative management
Author(s):

Lydia M. Jorge

and Obi Ekwenna

DOI:
10.1093/med/9780199651429.003.0028
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date: 22 October 2019

Four decades have passed since the first attempts at performing human intestinal transplants. The initial attempts were unsuccessful due to patients succumbing to complications of graft failure, overwhelming infections and sepsis, and rejection of the transplanted organs. Multivisceral transplantation (MVTx) involves transplantation of stomach, intestine, pancreas, and liver. A modified multivisceral transplant (MMVTx) excludes the liver. Outcomes have improved significantly as a result of modifications in surgical techniques along with research and progress in immunosuppressive therapy, the growing experience of specialized transplant centres, and improved postoperative management. MVTx is no longer considered an experimental treatment but a valid option to offer a chance of survival in patients with severe intestinal dysfunction and failure with associated complications from total parenteral nutrition.

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