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Liver disease: epidemiology, pathophysiology, and medical management 

Liver disease: epidemiology, pathophysiology, and medical management
Liver disease: epidemiology, pathophysiology, and medical management

Andre De Wolf

, Paul Martin

, and Hui-Hui Tan

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date: 11 August 2020

Liver transplantation is the treatment of choice for patients with ESLD, acute liver failure, or small hepatocarcinomas. The procedure consitutes a major challenge to the surgical team with its associated risks and complications. The natural history of the patient’s disease must be carefully weighed against the anticipated survival after liver transplantation.Because the liver plays a major role in many physiological body functions, ranging from protein and coagulation factor synthesis to maintaining glucose metabolism, it is no surprise that severe liver disease impacts the whole body. In this chapter we present the epidemiology of liver disease, its pathophysiological consequences, and the medical management options.

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