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Diabetes mellitus: epidemiology, pathophysiology, and treatment 

Diabetes mellitus: epidemiology, pathophysiology, and treatment
Diabetes mellitus: epidemiology, pathophysiology, and treatment

Piero Marchetti

, Margherita Occhipinti

, Gabriella Amorese

, and Ugo Boggi

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date: 22 October 2019

On average,diabetes mellitus causes 4 million deaths in the 20–79age group or 6.8% of global all-cause mortality in this age group. Diabetes mellitus is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion and/or insulin action, with defects of the pancreatic β‎-cells playing a key role. It is one of the most common chronic diseases in nearly every country, continues to increase in number and significance (mainly due to changes in lifestyle leading to decreased physical activity and obesity), and is associated with high morbidity and mortality. In this chapter indications for pancreatic transplant surgery in the diabetic patient as well as the stages of primary care referral, surgical outpatients, preoperative assessment, hospital admission, surgery, postoperative care and discharge, and long-term management are presented and discussed.

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