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Xenotransplantation 

Xenotransplantation
Chapter:
Xenotransplantation
Author(s):

Kazuhiko Yamada

, Joseph Scalea

, and Masayuki Tasaki

DOI:
10.1093/med/9780199651429.003.0012
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date: 23 August 2019

Xenotransplantation remains on the cutting edge of transplantation science and represents the most viable option for a large-scale expansion of the organ donor pool. The most compelling reason to pursue xenotransplantation is the obvious imbalance between supply and demand for transplantable organs. The burgeoning fields of stem cell biology and tissue engineering may offer solutions as well, but these technologies will likely require many more years of research before clinically applicable protocols are developed. At present, xenotransplantation, despite its hurdles, remains the most encouraging potential solution to the donor organ shortage. This chapter reviews briefly the history of xenotransplantation, summarizes the current state of the art, and presents what the authors consider to be the most likely areas of future success. It describes in detail the advantages of xenotransplantation over allotransplantation, as well as the surgical approaches to xenotransplantation. It focuses on the science and procedures necessary to understand and to safely reproduce the authors’ institution’s results with GalT-KO kidney transplantation and cotransplantation with vascularized thymus using GalT-KO pig donors. To date, these data demonstrate the best results with xenotransplantation in a preclinical model of life-supporting renal xenotransplantation.

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