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Transplant immunology 

Transplant immunology
Chapter:
Transplant immunology
Author(s):

Phillip Ruiz

, Junichiro Sageshima

, George Burke

, Linda Chen

, and Gaetano Ciancio

DOI:
10.1093/med/9780199651429.003.0011
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date: 26 August 2019

The identification of the intricate and multiple means by which the immune system serves as a principal impediment to solid organ graft survival has given rise to the development of an increasing number of highly effective immunosuppressive agents. At this point in time, additional ways of interrupting and negating the immune pathways have resulted in improved short-term graft survival and lessened patient mortality. Unfortunately, immunosuppressive drug-associated toxicities still remain as a serious set of transplant morbidities and long-term graft survival is currently remaining at unacceptably high levels. As our understanding of the precise mechanisms of immune effector and enhancement mechanisms evolves there will be concomitant opportunities to develop agents that will specifically enhance graft survival with minimal complications to the host.

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