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Sambit Mukhopadhyay

, Edward Morris

, and Sabaratnam Arulkumaran

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date: 24 June 2021

Jaundice complicates one in 1500 pregnancies. Viral hepatitis accounts for the majority of cases, while obstetric cholestasis, gallstones, hyperemesis gravidarum, acute fatty liver, and hypertensive diseases of pregnancy form other important aetiologies. Physiological changes of pregnancy are associated with mild cholestasis and elevated serum levels of alkaline phosphatase, fibrinogen, and most clotting factors. Serum protein concentrations and levels of serum transaminases are slightly reduced in normal pregnancy, while bilirubin levels do not show a significant change. The chapter covers the causes of jaundice in pregnancy, the effect of jaundice on mother and fetus, and assessment and management.

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