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Enda McVeigh

, John Guillebaud

, and Roy Homburg

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date: 23 September 2021


Mechanism of action and effectiveness



Problems and disadvantages


Counselling and ongoing supervision

In the UK, the only injectable contraceptives licensed for long-term use are depot medroxyprogesterone acetate (DMPA) and, since 2013, the same progestogen given subcutaneously as Sayana Press®.

WHO data indicate that DMPA users have a reduced risk of cancer, with no overall increased risk of cancers of the breast, ovary, or cervix, and a 5-fold reduction in the risk of carcinoma of the endometrium (relative risk 0.2)....

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