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Immunoglobulin constant regions 

Immunoglobulin constant regions
Chapter:
Immunoglobulin constant regions
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0008
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date: 04 April 2020

Antibodies not only have recognition sites for antigens, characterized by regions of high variability in the antibody variable regions, but also contain constant regions. Furthermore, different constant region structures became evident as the different antibody ‘isotypes’ were revealed. In this chapter the discovery of the different isotypic antibodies and the structural differences in their constant regions as well as their physiological sites of action and roles, as far as they are known, are explored and described. In addition, the discovery of polymorphic differences in the same constant region chains of the same species and the implications of their existence are explored.

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