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The cellular reformation 

The cellular reformation
The cellular reformation

Anthony Rees

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date: 19 January 2022

By the beginning of the 1950s, exactly how antibodies recognized antigens and how they were produced in such variety were still largely unknown. This would change with the revolutionary ideas of Jerne, Burnet, Talmage, Nossal, Lederberg, and others. The concept of ‘one cell, one antibody’ would be firmly established by the work of these researchers and along with the key experiments of many others would provide a tipping point for molecular immunology that would provide a rich tapestry of research activity for a large number of cell biologists and biochemists. Despite these important advances, and while providing a cellular explanation for antibody production, the question of how antibody diversity was acquired or generated would remain unexplained for more than two decades.

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