Show Summary Details
Page of

The cellular reformation 

The cellular reformation
Chapter:
The cellular reformation
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0005
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 October 2020

By the beginning of the 1950s, exactly how antibodies recognized antigens and how they were produced in such variety were still largely unknown. This would change with the revolutionary ideas of Jerne, Burnet, Talmage, Nossal, Lederberg, and others. The concept of ‘one cell, one antibody’ would be firmly established by the work of these researchers and along with the key experiments of many others would provide a tipping point for molecular immunology that would provide a rich tapestry of research activity for a large number of cell biologists and biochemists. Despite these important advances, and while providing a cellular explanation for antibody production, the question of how antibody diversity was acquired or generated would remain unexplained for more than two decades.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.