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The foundations of antibody-antigen recognition emerge 

The foundations of antibody-antigen recognition emerge
The foundations of antibody-antigen recognition emerge

Anthony Rees

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date: 22 September 2020

The structure and properties of proteins were still clouded in uncertainty during the 1930s. Theories abounded in the absence of definitive experimental information. During the decade from the mid-1930s on the great Linus Pauling had begun to address the special property of antigen recognition by antibodies and proposed models attempting to explain how what was believed to be a limited population of antibodies could recognize a diverse universe of antigens. Experimental advances took place that added electrophoresis to ultracentrifugation, further enhancing the protein chemistry armamentarium and allowing separation of antibody fractions in serum. At the same time, the question of antibody production and its cellular mechanisms began to be teased out by the advancing army of cell biologists.

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