Show Summary Details
Page of

The foundations of antibody-antigen recognition emerge 

The foundations of antibody-antigen recognition emerge
Chapter:
The foundations of antibody-antigen recognition emerge
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0004
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 22 September 2020

The structure and properties of proteins were still clouded in uncertainty during the 1930s. Theories abounded in the absence of definitive experimental information. During the decade from the mid-1930s on the great Linus Pauling had begun to address the special property of antigen recognition by antibodies and proposed models attempting to explain how what was believed to be a limited population of antibodies could recognize a diverse universe of antigens. Experimental advances took place that added electrophoresis to ultracentrifugation, further enhancing the protein chemistry armamentarium and allowing separation of antibody fractions in serum. At the same time, the question of antibody production and its cellular mechanisms began to be teased out by the advancing army of cell biologists.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.