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Antibodies: The therapeutic future 

Antibodies: The therapeutic future
Chapter:
Antibodies: The therapeutic future
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0017
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date: 22 September 2020

In this short ‘prospective’ the author suggest directions, currently poorly targeted by the academic and commercial research and development communities, that antibody-related therapies may take in the future. Many current therapeutic antibody developments are targeted at cancer but the escapology abilities of many tumours often block truly effective therapy. When considering antibody therapy for brain tumours, the blockading blood-brain barrier creates an access problem not yet really resolved. Again, the treatment of pregnant mothers with therapeutic antibodies can offer major advantages for the mother but in some instances passively transfer disadvantageous toxicities for the foetus. In all three of these areas there is reason to take a step back and re-evaluate the cost-benefit of current therapies and how they might be improved.

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