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Antibody engineering: Improving on natural immunity 

Antibody engineering: Improving on natural immunity
Chapter:
Antibody engineering: Improving on natural immunity
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0014
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date: 29 October 2020

Evolving the antibody phenotypic repertoire by protein engineering has opened up extraordinary possibilities for defeating many infectious diseases, cancer, haemolytic disorders, and even autoimmune diseases. Antibody constructions, impossible to produce via in vivo processes, have generated an entirely new arsenal of therapeutic agents, many of which are used in clinical treatment or are in clinical development. In this chapter the discovery path of some of the engineering constructions based on natural antibodies is described. In addition, methods that allowed protein engineers and immunologists to by-pass immunization, by display of antibody fragments on bacteriophage particles in flambuoyant library constructions, drove the discovery of many new antigen specificities, catapulting the antibody discovery process in a massive fast-forward process.

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