Show Summary Details
Page of

Antibody engineering: Improving on natural immunity 

Antibody engineering: Improving on natural immunity
Antibody engineering: Improving on natural immunity

Anthony Rees

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 28 January 2022

Evolving the antibody phenotypic repertoire by protein engineering has opened up extraordinary possibilities for defeating many infectious diseases, cancer, haemolytic disorders, and even autoimmune diseases. Antibody constructions, impossible to produce via in vivo processes, have generated an entirely new arsenal of therapeutic agents, many of which are used in clinical treatment or are in clinical development. In this chapter the discovery path of some of the engineering constructions based on natural antibodies is described. In addition, methods that allowed protein engineers and immunologists to by-pass immunization, by display of antibody fragments on bacteriophage particles in flambuoyant library constructions, drove the discovery of many new antigen specificities, catapulting the antibody discovery process in a massive fast-forward process.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.