Show Summary Details
Page of

Antibody structure prediction and development of humanization strategies 

Antibody structure prediction and development of humanization strategies
Chapter:
Antibody structure prediction and development of humanization strategies
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0013
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 22 September 2020

With more than a million antibodies in the human repertoire, the determination of the three-dimensional structures of all functionally interesting antibodies is an improbable task. To avoid this potential cul-de-sac, methods for computer modelling of the three-dimensional structures of antibodies were developed. These modelling methods for antibodies, preceded by a long, intensive development of protein structure analysis and simulation ably assisted by theoretical chemistry and computer graphics methods, led to giant steps in our ability to modify the structure of antibodies. Coupled with new ways of manipulating DNA to make site-specific changes in vitro, revolutionary approaches for converting rodent antibodies into their human counterparts became possible, with enormous impact on the development of therapeutic antibody modalities.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.