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Antibody structure prediction and development of humanization strategies 

Antibody structure prediction and development of humanization strategies
Antibody structure prediction and development of humanization strategies

Anthony Rees

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date: 21 May 2022

With more than a million antibodies in the human repertoire, the determination of the three-dimensional structures of all functionally interesting antibodies is an improbable task. To avoid this potential cul-de-sac, methods for computer modelling of the three-dimensional structures of antibodies were developed. These modelling methods for antibodies, preceded by a long, intensive development of protein structure analysis and simulation ably assisted by theoretical chemistry and computer graphics methods, led to giant steps in our ability to modify the structure of antibodies. Coupled with new ways of manipulating DNA to make site-specific changes in vitro, revolutionary approaches for converting rodent antibodies into their human counterparts became possible, with enormous impact on the development of therapeutic antibody modalities.

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