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Transmission and catabolism of IgG 

Transmission and catabolism of IgG
Chapter:
Transmission and catabolism of IgG
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0010
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date: 23 October 2020

Transfer of immunity to the unborn foetus is a characteristic of all mammals and was first described at the beginning of the twentieth century. It would take a great deal of zoological exploration and cell biological and biochemical analysis to understand just how the mother transfers antibodies to her unborn child. A molecular explanation would not arrive until the 1980s and with it would also come an understanding of how the catabolism of antibodies in the circulation is controlled. The importance of understanding the benefits and dangers of this materno-foetal transfer would lead to therapeutic interventions in particular clinical situations, protecting both mother and child.

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