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Antibody pre-history: The emergence of empirical immunology 

Antibody pre-history: The emergence of empirical immunology
Chapter:
Antibody pre-history: The emergence of empirical immunology
Author(s):

Anthony Rees

DOI:
10.1093/med/9780199646579.003.0001
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date: 26 October 2020

In this chapter, the early vaccination experiments of Jenner together with the careful experimentation of Robert Koch leading to his famous ‘postulates’; the often combative relationships between Koch, Pasteur, and their contemporaries; the famous public animal anthrax vaccination experiment at Pouilly-le-fort with its covert scientific anomalies;, and the successful treatment of a young boy by an attenuated rabies virus are relived. The end of the nineteenth century was a period riddled with controversy, uncertainty, and revelation, dominated by the traditional chemistry schools of Germany and Austria and the creative experimental developments in France. Such influences often hindered rather than stimulated acceptance of new immunological ideas.

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