- Chapter 1 Biological aspects of human ageing
- Chapter 2 Psychometric assessment in older people
- Chapter 3 The sociology of ageing
- Chapter 4 Transforming concepts of ageing: three case studies from anthropology
- Chapter 5 Epidemiology of old age psychiatry: an overview of concepts and main studies
- Chapter 6 Neuropathology
- Chapter 7 Neurochemical pathology of dementia
- Chapter 8 Molecular genetics and biology of dementia
- Chapter 9 Psychiatric assessment of older people
- Chapter 10 Clinical cognitive assessment
- Chapter 11 Physical assessment of older patients
- Chapter 12 Neuroimaging
- Chapter 13 Psychopharmacology in older people
- Chapter 14 Brain stimulation therapies
- Chapter 15 Person- and relationship-centred dementia care: past, present, and future
- Chapter 16 Psychological treatments
- Chapter 17 Cognitive behaviour therapy
- Chapter 18 Interpersonal psychotherapy
- Chapter 19 Psychodynamic psychotherapy
- Chapter 20 Family therapy
- Chapter 21 Nonpharmacological interventions in care homes
- Chapter 22 Principles of service provision in old age psychiatry
- Chapter 23 Primary care management of older people with mental health problems
- Chapter 24 Memory assessment services
- Chapter 25 Liaison old age psychiatry
- Chapter 26 Social care
- Chapter 27 Care homes for older people
- Chapter 28 Palliative care and end of life care
- Chapter 29 The concept of dementia
- Chapter 30 Hello, I’m me! Living well with dementia
- Chapter 31 Epidemiology of dementia
- Chapter 32 Mild Cognitive Impairment and predementia syndromes
- Chapter 33 Alzheimer’s disease
- Chapter 34 Vascular and mixed dementias
- Chapter 35 Dementia with Lewy bodies and Parkinson’s disease dementia
- Chapter 36 Frontotemporal dementia
- Chapter 37 Neurological dementias
- Chapter 38 Pharmacological treatment of dementia
- Chapter 39 Management of dementia
- Chapter 40 Delirium
- Chapter 41 The experience of depression
- Chapter 42 Depression in older people
- Chapter 43 Suicide and attempted suicide in older people
- Chapter 44 Manic syndromes in old age
- Chapter 45 Anxiety disorders in older people
- Chapter 46 Late-onset schizophrenia
- Chapter 47 Personal experience of lifelong illness
- Chapter 48 Severe and enduring mental illness
- Chapter 49 Alcohol and substance abuse in older people
- Chapter 50 Older people with learning disabilities
- Chapter 51 Sleep disorders
- Chapter 52 The effect of ageing on personality
- Chapter 53 Personality in later life: personality disorder and the effects of illness on personality
- Chapter 54 Sexuality in later life
- Chapter 55 Ethics and old age psychiatry
- Chapter 56 Mental capacity and decision-making
- Chapter 57 Ethics of living and dying with dementia
- Chapter 58 The ethics of caring
- Chapter 59 Elder abuse
- Chapter 60 Crime, mental illness, and older people
- Chapter 61 Testamentary capacity
- Chapter 62 Driving and psychiatric illness in later life
- Chapter 63 The law relating to mental capacity and mental health
(p. 107) Neurochemical pathology of dementia
- Chapter:
- (p. 107) Neurochemical pathology of dementia
- Author(s):
Margaret Ann Piggott
- DOI:
- 10.1093/med/9780199644957.003.0007
This chapter considers the neurodegenerative disorders Alzheimer’s disease (AD), Lewy body dementias (dementia with Lewy bodies (DLB) and Parkinson’s disease dementia(PDD)), frontotemporal dementia (FTD); and also vascular dementia (VaD) which results from cerebrovascular disease. These different conditions, which give rise to dementia syndromes, each have distinct neurochemical pathologies, with important implications for treatment. As increased age is the common risk factor generally associated with dementing illnesses, neurochemical changes are set in the context of the changes which occur during ageing. A detailed understanding of the neurotransmitter function in each condition can lead to rational drug design and treatment strategies appropriate for each group of patients. Neurochemical pathology in transmitter systems underlying clinical features of these disorders are reviewed.
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- Chapter 1 Biological aspects of human ageing
- Chapter 2 Psychometric assessment in older people
- Chapter 3 The sociology of ageing
- Chapter 4 Transforming concepts of ageing: three case studies from anthropology
- Chapter 5 Epidemiology of old age psychiatry: an overview of concepts and main studies
- Chapter 6 Neuropathology
- Chapter 7 Neurochemical pathology of dementia
- Chapter 8 Molecular genetics and biology of dementia
- Chapter 9 Psychiatric assessment of older people
- Chapter 10 Clinical cognitive assessment
- Chapter 11 Physical assessment of older patients
- Chapter 12 Neuroimaging
- Chapter 13 Psychopharmacology in older people
- Chapter 14 Brain stimulation therapies
- Chapter 15 Person- and relationship-centred dementia care: past, present, and future
- Chapter 16 Psychological treatments
- Chapter 17 Cognitive behaviour therapy
- Chapter 18 Interpersonal psychotherapy
- Chapter 19 Psychodynamic psychotherapy
- Chapter 20 Family therapy
- Chapter 21 Nonpharmacological interventions in care homes
- Chapter 22 Principles of service provision in old age psychiatry
- Chapter 23 Primary care management of older people with mental health problems
- Chapter 24 Memory assessment services
- Chapter 25 Liaison old age psychiatry
- Chapter 26 Social care
- Chapter 27 Care homes for older people
- Chapter 28 Palliative care and end of life care
- Chapter 29 The concept of dementia
- Chapter 30 Hello, I’m me! Living well with dementia
- Chapter 31 Epidemiology of dementia
- Chapter 32 Mild Cognitive Impairment and predementia syndromes
- Chapter 33 Alzheimer’s disease
- Chapter 34 Vascular and mixed dementias
- Chapter 35 Dementia with Lewy bodies and Parkinson’s disease dementia
- Chapter 36 Frontotemporal dementia
- Chapter 37 Neurological dementias
- Chapter 38 Pharmacological treatment of dementia
- Chapter 39 Management of dementia
- Chapter 40 Delirium
- Chapter 41 The experience of depression
- Chapter 42 Depression in older people
- Chapter 43 Suicide and attempted suicide in older people
- Chapter 44 Manic syndromes in old age
- Chapter 45 Anxiety disorders in older people
- Chapter 46 Late-onset schizophrenia
- Chapter 47 Personal experience of lifelong illness
- Chapter 48 Severe and enduring mental illness
- Chapter 49 Alcohol and substance abuse in older people
- Chapter 50 Older people with learning disabilities
- Chapter 51 Sleep disorders
- Chapter 52 The effect of ageing on personality
- Chapter 53 Personality in later life: personality disorder and the effects of illness on personality
- Chapter 54 Sexuality in later life
- Chapter 55 Ethics and old age psychiatry
- Chapter 56 Mental capacity and decision-making
- Chapter 57 Ethics of living and dying with dementia
- Chapter 58 The ethics of caring
- Chapter 59 Elder abuse
- Chapter 60 Crime, mental illness, and older people
- Chapter 61 Testamentary capacity
- Chapter 62 Driving and psychiatric illness in later life
- Chapter 63 The law relating to mental capacity and mental health