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Psychopharmacology in older people 

Psychopharmacology in older people
Psychopharmacology in older people

Craig W. Ritchie

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date: 31 July 2021

It is well recognised that older people are particularly sensitive to psychotropic medication. In general, pharmacological interventions in the elderly pose specific problems due to the patient exhibiting both altered pharmacokinetic drug profiles due to gerontological effects on absorption, distribution, metabolism and elimination of drug and pharmacodynamic effects related to aging and polypharmacy. Adherence to medication in later life also mediates sub-optimal pharmacological care. Finally, the effects of comorbidities which accumulate with advancing years should also influence prescribing practice in the elderly. The general principles underlying these changes and observations are discussed with specific examples listed to illustrate these points.

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