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Nociceptive signalling in the periphery and spinal cord 

Nociceptive signalling in the periphery and spinal cord
Nociceptive signalling in the periphery and spinal cord

Suellen M. Walker

and Mark L. Baccei

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date: 16 September 2021

Responses to painful or noxious stimuli are functional at birth. However, postnatal changes in the transmitters, receptors, and pathways involved in nociceptive signalling result in significant age-related changes in the nature and degree of response. Noxious mechanical, thermal, and chemical stimuli are detected by peripheral nociceptors, transduced into electrical stimuli, and transmitted to the spinal cord. Within the spinal cord, there are significant postnatal changes in the balance of inhibitory and excitatory signalling, that not only influence the acute response to afferent input, but can also underlie long-term alterations in sensory processing following tissue injury in early life. Evaluating age-related changes in nociceptive signalling is essential not only for understanding acute behavioural responses to noxious stimuli, but also for identifying the most appropriate and effective pain management interventions at different developmental ages.

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