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Principles of pain pharmacology in paediatrics 

Principles of pain pharmacology in paediatrics
Principles of pain pharmacology in paediatrics

Kim Chau

and Gideon Koren

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date: 29 July 2021

Changes during growth and development may profoundly alter the pharmacokinetic and pharmacodynamics profile of medications in children of different ages, and in comparison to adults. Genetic factors can also influence the disposition and action of a drug, and contribute to interindividual differences in clinical response. Safe and effective pharmacological management of pain in neonates, infants, and children requires a thorough understanding of the principles of analgesic pharmacology in paediatric patients. Analgesic dosing regimens should take into account the severity of pain, the age or developmental state of the infant, and the therapeutic window of the drug.

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