This two-volume work of 91 chapters covers all aspects of practice in anaesthesia. Volume 1 addresses the underpinning sciences of anaesthesia including physiology, pharmacology, physics, anaesthetic equipment, statistics, and evidence-based anaesthesia. Volume 1 also outlines the fundamental principles of anaesthetic practice including ethics, risk, informatics and technology for anaesthesia, human factors and simulation in anaesthetic practice, safety and quality assurance in anaesthesia, teaching, research, and outcomes, as well as all stages of the perioperative journey including preoperative assessment and optimization for anaesthesia, intraoperative monitoring, avoiding and managing hazards, post-surgical analgesia and acute pain management, and post-surgical anaesthetic complications. Volume 2 focuses on the clinical aspects of anaesthesia, including procedures, techniques and therapies, regional anaesthesia, the conduct of anaesthesia by surgical specialty, and paediatric and neonatal anaesthesia, including the resuscitation, stabilization, and transfer of sick and injured children. The clinical second volume also addresses the conduct of anaesthesia outside the operating theatre, including pre-hospital care, anaesthesia in remote locations, and military anaesthesia. The core knowledge for providing anaesthesia and managing comorbidities is provided, and in addition, those aspects of intensive care and pain medicine that are core knowledge for the general anaesthetist are covered. The book brings together key concepts, pertinent research from ongoing scientific endeavours, and clinical practice guidelines.