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Statistical basis of clinical trials 

Statistical basis of clinical trials
Statistical basis of clinical trials

Jeremy Prout

, Tanya Jones

, and Daniel Martin

Page of

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date: 17 April 2021

This chapter summarizes some aspects of study design and statistical analysis to allow the anaesthetist to appraise research. Types of observational study are described and aspects of interventional studies such as sample size calculation and power are explained. Research governance, phases of drug trials and levels of evidence are described. A section on statistical analysis includes expression of proportion for binary data (odds ratio, number needed to treat) and use of probability and confidence intervals to measure statistical significance.

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