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Non-degenerative Choreas 

Non-degenerative Choreas
Non-degenerative Choreas

Francisco Cardoso

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date: 27 October 2021

Non-genetic choreas can have a myriad of causes which fit into the following categories: autoimmune, vascular, drug-induced, infectious, metabolic and toxic encephalopathy, and miscellaneous. Sydenham’s chorea, an autoimmune condition related to streptococcal infection, is the most common cause of chorea in children worldwide. In contrast, vascular disease, particularly in association with diabetes mellitus type 2, accounts for the majority of non-genetic choreas in adults. HIV infection, systemic lupus erythematosus, drugs, paraneoplastic syndromes, hyperthyroidism, brain neoplasms, etc. are also causes of chorea. The aim of this chapter is to discuss the epidemiology, clinical features, diagnosis, pathogenesis, and management of acquired causes of chorea.

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