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Fibrous dysplasia 

Fibrous dysplasia
Fibrous dysplasia

Roger Smith

and Paul Wordsworth

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date: 28 November 2020

Fibrous dysplasia is a rare heterogenous disorder resulting from postzygotic activating mutation of the GNAS gene. Its main effect is on the skeleton. According to the distribution of the mutation this may be monostotic or polyostotic or, when widespread, the McCune–Albright syndrome. Treatment with bisphosphonates and denosumab is described.

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