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Stuart Crisp

and Jo Rainbow

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date: 20 April 2021

Anaemia 384

Haemoglobinopathies: sickle cell anaemia 388

Haemoglobinopathies: thalassaemia 392

Bleeding and bruising 394

Haemophilia 398

Further reading 400

Anaemia arises when the haemoglobin falls below normal range for age (see Table 20.1).

Anaemia is usually of gradual onset, presenting with non-specific malaise and lethargy, but acute crises, e.g. haemolytic, or aplastic, can arise. The latter are more common if the marrow is under stress, e.g. haemoglobinopathy, acute leukaemia. There are also some rare bone marrow disorders, e.g. Diamond Blackfan, that result in isolated anaemia or Fanconi's giving rise to pancytopenia....

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