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Autoimmune eye disease 

Autoimmune eye disease
Autoimmune eye disease

Gavin P Spickett

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date: 23 January 2021



Tubulointerstitial nephritis and uveitis (TINU)

Vogt–Koyanagi–Harada disease (VKH)

Cancer-associated retinopathy and uveitis

Birdshot retinopathy


Ocular cicatricial pemphigoid

Sympathetic ophthalmitis

Idiopathic orbital inflammation (orbital pseudo-tumour)

The eye has a number of interesting immunological properties which alter the propensity for immune-mediated disease, including the curious feature that antigen injected into the anterior chamber induces tolerance rather than immunity. In addition, the eye has no true lymphatics, relatively poor vascularity, and, as the retina is an extension of the CNS, there is a blood–retinal barrier which limits passage of molecules in either direction. Ocular involvement is a common feature of many connective tissue and vasculitic diseases....

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