- Section 1 ICU organization and management
- Section 2 Pharmacotherapeutics
- Section 3 Resuscitation
- Section 4 The respiratory system
- Section 5 The cardiovascular system
- Section 6 The gastrointestinal system
- Section 7 Nutrition
- Section 8 The renal system
- Section 9 The neurological system
- Section 10 The metabolic and endocrine systems
- Section 11 The haematological system
- Section 12 The skin and connective tissue
- Section 13 Infection
- Section 14 Inflammation
- Section 15 Poisoning
- Part 15.1 Principles of management
- Part 15.2 Management of specific poisons
- Chapter 317 Management of salicylate poisoning
- Chapter 318 Management of acetaminophen (paracetamol) poisoning
- Chapter 319 Management of opioid poisoning
- Chapter 320 Management of benzodiazepine poisoning
- Chapter 321 Management of tricyclic antidepressant poisoning
- Chapter 322 Management of poisoning by amphetamine or ecstasy
- Chapter 323 Management of digoxin poisoning
- Chapter 324 Management of cocaine poisoning
- Chapter 325 Management of <span xml:lang="ell">β</span>-blocker and calcium channel blocker poisoning
- Chapter 326 Management of cyanide poisoning
- Chapter 327 Management of alcohol poisoning
- Chapter 328 Management of carbon monoxide poisoning
- Chapter 329 Management of corrosive poisoning
- Chapter 330 Management of pesticide and agricultural chemical poisoning
- Chapter 331 Management of radiation poisoning
- Section 16 Trauma
- Section 17 Physical disorders
- Section 18 Pain and sedation
- Section 19 General surgical and obstetric intensive care
- Section 20 Specialized intensive care
- Section 21 Recovery from critical illness
- Section 22 End-of-life care
(p. 1514) Management of specific poisons
Salicylates are weak acids that work as neurotoxins. The goal of management is to keep salicylates out of the brain and enhance elimination. Acute salicylate toxicity manifests as tinnitus, nausea, vomiting, and hyperventilation in a patient who takes a single large ingestion. Chronic salicylate toxicity is associated with long-term use, has a more insidious onset, and symptoms tend to be less severe, resulting in delayed diagnosis. It is more commonly seen in elderly patients. Therapeutic interventions for toxicity include gastrointestinal decontamination, serum and urine alkalinization, and haemodialysis. Mechanical ventilation may lead to clinical deterioration and death in a salicylate-poisoned patient due to worsening acidosis from respiratory failure. This results in severe acidosis, cerebral oedema, pulmonary oedema, and cardiac arrest.
Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.
Please subscribe or login to access full text content.
If you have purchased a print title that contains an access token, please see the token for information about how to register your code.
For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.
- Section 1 ICU organization and management
- Section 2 Pharmacotherapeutics
- Section 3 Resuscitation
- Section 4 The respiratory system
- Section 5 The cardiovascular system
- Section 6 The gastrointestinal system
- Section 7 Nutrition
- Section 8 The renal system
- Section 9 The neurological system
- Section 10 The metabolic and endocrine systems
- Section 11 The haematological system
- Section 12 The skin and connective tissue
- Section 13 Infection
- Section 14 Inflammation
- Section 15 Poisoning
- Part 15.1 Principles of management
- Part 15.2 Management of specific poisons
- Chapter 317 Management of salicylate poisoning
- Chapter 318 Management of acetaminophen (paracetamol) poisoning
- Chapter 319 Management of opioid poisoning
- Chapter 320 Management of benzodiazepine poisoning
- Chapter 321 Management of tricyclic antidepressant poisoning
- Chapter 322 Management of poisoning by amphetamine or ecstasy
- Chapter 323 Management of digoxin poisoning
- Chapter 324 Management of cocaine poisoning
- Chapter 325 Management of <span xml:lang="ell">β</span>-blocker and calcium channel blocker poisoning
- Chapter 326 Management of cyanide poisoning
- Chapter 327 Management of alcohol poisoning
- Chapter 328 Management of carbon monoxide poisoning
- Chapter 329 Management of corrosive poisoning
- Chapter 330 Management of pesticide and agricultural chemical poisoning
- Chapter 331 Management of radiation poisoning
- Section 16 Trauma
- Section 17 Physical disorders
- Section 18 Pain and sedation
- Section 19 General surgical and obstetric intensive care
- Section 20 Specialized intensive care
- Section 21 Recovery from critical illness
- Section 22 End-of-life care