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Neuroprotective agents in critical illness 

Neuroprotective agents in critical illness
Chapter:
Neuroprotective agents in critical illness
Author(s):

Jerrold L. Perrott

and Steven C. Reynolds

DOI:
10.1093/med/9780199600830.003.0048
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date: 25 February 2020

The prevention and reduction of secondary injury following primary CNS insult is an important goal in critically-ill patients. Numerous pharmacological therapies have been studied as potential neuroprotective agents with few translating from research to clinical benefit. These are nimodipine and statins in aneurysmal subarachnoid haemorrhage and phenytoin in traumatic brain injury. Additionally, in traumatic brain injury, clinical studies have identified that corticosteroids and albumin colloid resuscitation are associated with increased risk of mortality, and as such should be avoided. Future research into new pharmacological neuroprotective strategies is warranted.

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