Show Summary Details
Page of

Physical consequences of critical illness 

Physical consequences of critical illness
Physical consequences of critical illness

Margaret S. Herridge

and Jane Batt

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 05 July 2022

Critical illness is an important life event with a lasting legacy. Patients acquire new nerve, brain, and muscle injury, and sustain important functional dependencies that have clear consequences for subsequent health-related quality of life. Intensive care unit (ICU)-acquired weakness is a prevalent and likely ubiquitous consequence of severe illness. Patients degrade their skeletal muscle within hours of ICU admission through upregulation of different proteolytic pathways, regardless of the inciting aetiology. This may support an approach to muscle injury, sustained disability and subsequent approach to rehabilitation that is aetiologically neutral, and linked to molecular pathophysiology and associated functional outcome. The physical devastation of critical illness affects the entire family unit and family caregivers need to be acknowledged as important risk modifiers for outcome and have their needs addressed as part of an interprofessional rehabilitation intervention.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.