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Adaptive immunity in critical illness 

Adaptive immunity in critical illness
Chapter:
Adaptive immunity in critical illness
Author(s):

Sean F. Monaghan

and Alfred Ayala

DOI:
10.1093/med/9780199600830.003.0311
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date: 30 November 2020

The development of sepsis remains a significant morbid event facing the critically-ill/severely-injured patient and while substantial improvements in supportive care have been made, a true molecular pharmacological treatment directed at mitigating the development of this condition has remained elusive. This is due, at least in part, to our lack of appreciation of the complex and intertwined changes in the nature of not only the innate, but also the adaptive immune response and how they affect our response to septic challenge. Here, we consider some of the aspects of the adaptive immune response, how it changes in the response to sepsis, possible pathological processes contributing to patient/experimental animal susceptibility to poorer outcomes and where novel immune-therapeutic targets/biomarkers may exist.

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