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Ischaemia-reperfusion injury in the critically ill 

Ischaemia-reperfusion injury in the critically ill
Chapter:
Ischaemia-reperfusion injury in the critically ill
Author(s):

Mitchell P. Fink

DOI:
10.1093/med/9780199600830.003.0308
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date: 28 July 2021

Ischaemia/reperfusion (I/R) injury contributes to the pathogenesis of many common clinical conditions, including stroke, myocardial damage after percutaneous intervention for acute coronary artery occlusion, primary graft dysfunction after solid organ transplantation. The mechanisms that are responsible for I/R injury remain incompletely understood, but damage caused by reactive oxygen species (ROS) and reactive nitrogen species clearly is important. A number of therapeutic approaches, such as administration of ROS scavengers, are effective in animal models of I/R injury, but for the most part, translation of these findings into strategies that can clearly benefit patients has yet to be achieved.

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