- Section 1 ICU organization and management
- Section 2 Pharmacotherapeutics
- Section 3 Resuscitation
- Section 4 The respiratory system
- Section 5 The cardiovascular system
- Section 6 The gastrointestinal system
- Section 7 Nutrition
- Section 8 The renal system
- Section 9 The neurological system
- Section 10 The metabolic and endocrine systems
- Section 11 The haematological system
- Section 12 The skin and connective tissue
- Section 13 Infection
- Section 14 Inflammation
- Part 14.1 Physiology
- Part 14.2 Organ-specific biomarkers
- Part 14.3 Host response
- Chapter 303 The host response to infection in the critically ill
- Chapter 304 The host response to trauma and burns in the critically ill
- Chapter 305 The host response to hypoxia in the critically ill
- Chapter 306 Host–pathogen interactions in the critically ill
- Chapter 307 Coagulation and the endothelium in acute injury in the critically ill
- Chapter 308 Ischaemia-reperfusion injury in the critically ill
- Chapter 309 Repair and recovery mechanisms following critical illness
- Chapter 310 Neural and endocrine function in the immune response to critical illness
- Chapter 311 Adaptive immunity in critical illness
- Chapter 312 Immunomodulation strategies in the critically ill
- Chapter 313 Immunoparesis in the critically ill
- Part 14.4 Anaphylaxis
- Section 15 Poisoning
- Section 16 Trauma
- Section 17 Physical disorders
- Section 18 Pain and sedation
- Section 19 General surgical and obstetric intensive care
- Section 20 Specialized intensive care
- Section 21 Recovery from critical illness
- Section 22 End-of-life care
(p. 1471) Ischaemia-reperfusion injury in the critically ill
- Chapter:
- (p. 1471) Ischaemia-reperfusion injury in the critically ill
- Author(s):
Mitchell P. Fink
- DOI:
- 10.1093/med/9780199600830.003.0308
Ischaemia/reperfusion (I/R) injury contributes to the pathogenesis of many common clinical conditions, including stroke, myocardial damage after percutaneous intervention for acute coronary artery occlusion, primary graft dysfunction after solid organ transplantation. The mechanisms that are responsible for I/R injury remain incompletely understood, but damage caused by reactive oxygen species (ROS) and reactive nitrogen species clearly is important. A number of therapeutic approaches, such as administration of ROS scavengers, are effective in animal models of I/R injury, but for the most part, translation of these findings into strategies that can clearly benefit patients has yet to be achieved.
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- Section 1 ICU organization and management
- Section 2 Pharmacotherapeutics
- Section 3 Resuscitation
- Section 4 The respiratory system
- Section 5 The cardiovascular system
- Section 6 The gastrointestinal system
- Section 7 Nutrition
- Section 8 The renal system
- Section 9 The neurological system
- Section 10 The metabolic and endocrine systems
- Section 11 The haematological system
- Section 12 The skin and connective tissue
- Section 13 Infection
- Section 14 Inflammation
- Part 14.1 Physiology
- Part 14.2 Organ-specific biomarkers
- Part 14.3 Host response
- Chapter 303 The host response to infection in the critically ill
- Chapter 304 The host response to trauma and burns in the critically ill
- Chapter 305 The host response to hypoxia in the critically ill
- Chapter 306 Host–pathogen interactions in the critically ill
- Chapter 307 Coagulation and the endothelium in acute injury in the critically ill
- Chapter 308 Ischaemia-reperfusion injury in the critically ill
- Chapter 309 Repair and recovery mechanisms following critical illness
- Chapter 310 Neural and endocrine function in the immune response to critical illness
- Chapter 311 Adaptive immunity in critical illness
- Chapter 312 Immunomodulation strategies in the critically ill
- Chapter 313 Immunoparesis in the critically ill
- Part 14.4 Anaphylaxis
- Section 15 Poisoning
- Section 16 Trauma
- Section 17 Physical disorders
- Section 18 Pain and sedation
- Section 19 General surgical and obstetric intensive care
- Section 20 Specialized intensive care
- Section 21 Recovery from critical illness
- Section 22 End-of-life care