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Cardiac injury biomarkers in the critically ill 

Cardiac injury biomarkers in the critically ill
Chapter:
Cardiac injury biomarkers in the critically ill
Author(s):

Anthony S. McLean

and Stephen J. Huang

DOI:
10.1093/med/9780199600830.003.0301
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date: 26 January 2021

To be clinically relevant, a good cardiac biomarker should have four main characteristics. It should be organ-, disease- and stage-specific to be useful in diagnosis. Its release should be timely and its half-life should be long enough to make measurement possible and meaningful. Its serum or blood concentration should be proportional to disease severity; hence, can be used as a monitoring tool. Finally, their concentrations have implications on long-term outcomes. To date, only a handful of cardiac biomarkers have clinical relevance in the intensive care setting—cardiac troponins (as a marker of cardiac injury) and B-type natriuretic peptide (as a marker of cardiac stress) being probably the most useful. However, cautious interpretations of these biomarkers are needed in intensive care patients as several confounding factors can affect their concentrations.

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