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Pathophysiology and management of functional endocrine tumours in the critically ill 

Pathophysiology and management of functional endocrine tumours in the critically ill
Chapter:
Pathophysiology and management of functional endocrine tumours in the critically ill
Author(s):

Sara Nikravan

and Frederick Mihm

DOI:
10.1093/med/9780199600830.003.0264
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date: 27 February 2020

Thyroid hormones act on most tissues via nuclear T3 receptors. Thyroid hormones stimulate oxygen consumption and heat production, influence cell growth and maturation (central nervous system, bone), and modulate metabolism (carbohydrates, lipids, proteins, drugs). Treatment for presumed thyroid disease frequently has to be initiated before the results of diagnostic tests are available. Treatment of hyperthyroidism should result in the reduction of serum thyroid hormone levels and their action on peripheral tissues with concurrent treatment of the precipitating event. In severe hypothyroidism the choice of thyroid hormone (thyroxine or tri-iodothyronine), optimal dosing, and the route of administration remain controversial

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