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Pathophysiology, diagnosis, and assessment of acute or chronic hepatic failure 

Pathophysiology, diagnosis, and assessment of acute or chronic hepatic failure
Chapter:
Pathophysiology, diagnosis, and assessment of acute or chronic hepatic failure
Author(s):

Alastair O’Brien

DOI:
10.1093/med/9780199600830.003.0199
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date: 20 February 2020

Cirrhosis is an increasing problem and prognosis following intensive care unit admission is poor. Acute on chronic liver failure (ACLF) is a separate entity to cirrhosis with organ failure at the core of this syndrome. Infection and the associated systemic inflammatory responses are the most important precipitants of ACLF. Clinical assessment should follow the standard airway breathing circulation disability exposure approach to the critically-ill patient.

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