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Management of acute hepatic failure in the critically ill 

Management of acute hepatic failure in the critically ill
Management of acute hepatic failure in the critically ill

Deepak Joshi

and Georg Auzinger

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date: 21 May 2022

Acute liver failure occurs in patients with acute hepatic necrosis resulting in hepatic encephalopathy, jaundice and coagulopathy. Acute liver failure is a multisystem disorder. The management is initially supportive. Intravenous N-acetylcysteine is recommended for all patients. Brain dysfunction is common. Elective intubation is recommended for all patients who develop Grade III hepatic encephalopathy. Liver transplantation is an appropriate and viable treatment for acute liver failure. Early and safe transfer to a transplant centre for transplant assessment is advised.

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