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Management of acute non-cardiogenic pulmonary oedema 

Management of acute non-cardiogenic pulmonary oedema
Chapter:
Management of acute non-cardiogenic pulmonary oedema
Author(s):

Sébastien Tanaka

and Jacques Duranteau

DOI:
10.1093/med/9780199600830.003.0165
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date: 20 February 2020

Severe capillary leak is an important factor in the pathogenesis of organ dysfunction following inflammatory syndromes such as sepsis-induced acute lung injury and acute respiratory distress syndrome (ARDS). Various interventions, such as a conservative fluid strategy, albumin, and diuretics are designed to maintain an adequate intravascular colloid osmotic pressure, reduce capillary leak and reduce extravascular water. Of these, only a conservative, rather than liberal fluid strategy is currently recommended. Preclinical studies in ARDS and sepsis suggest that preventing microvascular leak may represent a viable therapeutic approach to prevent or ameliorate organ dysfunction. The challenge is to now go further with carefully designed clinical trials.

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