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Transplantation: immunology and immunosuppression 

Transplantation: immunology and immunosuppression
Chapter:
Transplantation: immunology and immunosuppression
Author(s):

Althea Mahon

, Karen Jenkins

, and Lisa Burnapp

DOI:
10.1093/med/9780199600533.003.0015
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date: 21 October 2020

Transplant immunology

Immunosuppression

Induction immunosuppression

Maintenance immunosuppression

Calcineurin inhibitors

Corticosteroids

Antimetabolites

Inhibitors of mammalian target of rapamycin (mTOR)

Treatment of acute rejection

Adherence to medications

What next in transplantation?

Further reading

The immune system provides a unique defence against physiological harm. Through a series of complex mechanisms, it is able to identify between molecules that are ‘self’ and ‘non-self’. The immunological response to a transplanted organ is a significant cause of graft failure in the recipient. Understanding it and why it happens makes it possible to develop strategies to overcome the barriers to successful Tx....

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