- Foreword
- Preface
- Acknowledgements
- Contributors
- List of abbreviations
- Part I Coronary heart disease
- Chapter 1 Epidemiology, outcomes, and quality of care
- Chapter 2 Lipids and cardiovascular disease
- Chapter 3 Myocardial ischaemia
- Chapter 4 Thrombosis, haemostasis, and platelet biology
- Chapter 5 Medical versus invasive management of coronary heart disease
- Chapter 6 Percutaneous coronary intervention
- Chapter 7 Percutaneous coronary intervention versus coronary artery bypass graft surgery
- Part II Cardiac electrophysiology and heart rhythm disturbances
- Chapter 8 Epidemiology and molecular foundation
- Chapter 9 Atrial fibrillation
- Chapter 10 Interventional electrophysiology
- Chapter 11 Anti-arrhythmic drug therapy
- Part III Heart failure
- Chapter 12 Epidemiology
- Chapter 13 Medical management
- Chapter 14 Cardiac resynchronization therapy
- Chapter 15 Non-ischaemic cardiomyopathy
- Chapter 16 Cardiac failure and transplantation
- Part IV Hypertension
- Chapter 17 Systemic arterial hypertension
- Chapter 18 Pulmonary arterial hypertension
- Part V Valvular heart disease
- Chapter 19 Epidemiology and intervention
- Chapter 20 Endocarditis
- Part VI Cardiac imaging
- Chapter 21 Echocardiography
- Chapter 22 Cardiovascular magnetic resonance
- Chapter 23 Cardiac computed tomography
- Part VII Congenital heart disease
- Chapter 24 Congenital heart disease
- Part VIII Obstetric cardiology
- Chapter 25 Obstetric cardiology
- Part IX Cardiac rehabilitation
- Chapter 26 Cardiac rehabilitation
- Index
(p. 258) Non-ischaemic cardiomyopathy
- Chapter:
- (p. 258) Non-ischaemic cardiomyopathy
- Author(s):
Dr Julian Ormerod
and Michael Frenneaux
- DOI:
- 10.1093/med/9780199594764.003.0015
From the glimpses provided in this chapter it will be clear that there have been huge advances in our understanding of the aetiological basis for the cardiomyopathies— particularly the molecular genetics—and of the pathophysiology of these disorders. However, it must be acknowledged that, thus far, these exciting data have not translated into specific therapies. Our recent paper demonstrating that the metabolic modulator perhexiline partially corrects cardiac energetic impairment in patients with hypertrophic cardiomyopathy, and that this translates into improved symptoms and exercise capacity, may be a forerunner of such therapeutic translation.
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- Foreword
- Preface
- Acknowledgements
- Contributors
- List of abbreviations
- Part I Coronary heart disease
- Chapter 1 Epidemiology, outcomes, and quality of care
- Chapter 2 Lipids and cardiovascular disease
- Chapter 3 Myocardial ischaemia
- Chapter 4 Thrombosis, haemostasis, and platelet biology
- Chapter 5 Medical versus invasive management of coronary heart disease
- Chapter 6 Percutaneous coronary intervention
- Chapter 7 Percutaneous coronary intervention versus coronary artery bypass graft surgery
- Part II Cardiac electrophysiology and heart rhythm disturbances
- Chapter 8 Epidemiology and molecular foundation
- Chapter 9 Atrial fibrillation
- Chapter 10 Interventional electrophysiology
- Chapter 11 Anti-arrhythmic drug therapy
- Part III Heart failure
- Chapter 12 Epidemiology
- Chapter 13 Medical management
- Chapter 14 Cardiac resynchronization therapy
- Chapter 15 Non-ischaemic cardiomyopathy
- Chapter 16 Cardiac failure and transplantation
- Part IV Hypertension
- Chapter 17 Systemic arterial hypertension
- Chapter 18 Pulmonary arterial hypertension
- Part V Valvular heart disease
- Chapter 19 Epidemiology and intervention
- Chapter 20 Endocarditis
- Part VI Cardiac imaging
- Chapter 21 Echocardiography
- Chapter 22 Cardiovascular magnetic resonance
- Chapter 23 Cardiac computed tomography
- Part VII Congenital heart disease
- Chapter 24 Congenital heart disease
- Part VIII Obstetric cardiology
- Chapter 25 Obstetric cardiology
- Part IX Cardiac rehabilitation
- Chapter 26 Cardiac rehabilitation
- Index