- Foreword
- Preface
- Acknowledgements
- Contributors
- List of abbreviations
- Part I Coronary heart disease
- Chapter 1 Epidemiology, outcomes, and quality of care
- Chapter 2 Lipids and cardiovascular disease
- Chapter 3 Myocardial ischaemia
- Chapter 4 Thrombosis, haemostasis, and platelet biology
- Chapter 5 Medical versus invasive management of coronary heart disease
- Chapter 6 Percutaneous coronary intervention
- Chapter 7 Percutaneous coronary intervention versus coronary artery bypass graft surgery
- Part II Cardiac electrophysiology and heart rhythm disturbances
- Chapter 8 Epidemiology and molecular foundation
- Chapter 9 Atrial fibrillation
- Chapter 10 Interventional electrophysiology
- Chapter 11 Anti-arrhythmic drug therapy
- Part III Heart failure
- Chapter 12 Epidemiology
- Chapter 13 Medical management
- Chapter 14 Cardiac resynchronization therapy
- Chapter 15 Non-ischaemic cardiomyopathy
- Chapter 16 Cardiac failure and transplantation
- Part IV Hypertension
- Chapter 17 Systemic arterial hypertension
- Chapter 18 Pulmonary arterial hypertension
- Part V Valvular heart disease
- Chapter 19 Epidemiology and intervention
- Chapter 20 Endocarditis
- Part VI Cardiac imaging
- Chapter 21 Echocardiography
- Chapter 22 Cardiovascular magnetic resonance
- Chapter 23 Cardiac computed tomography
- Part VII Congenital heart disease
- Chapter 24 Congenital heart disease
- Part VIII Obstetric cardiology
- Chapter 25 Obstetric cardiology
- Part IX Cardiac rehabilitation
- Chapter 26 Cardiac rehabilitation
- Index
(p. 132) (p. 133) Epidemiology and molecular foundation
- Author(s):
Dr Fu Siong Ng
and Nicholas Peters
- DOI:
- 10.1093/med/9780199594764.003.0008
Selecting a short list of landmark basic science and epidemiology papers in the field of cardiac electrophysiology for this chapter has been no easy task. For every paper listed in the following section, we have had to leave out several other equally important, high-impact papers. To help narrow down the list, we have had to come up with a restrictive definition of what makes a landmark paper.
Here we describe basic science and epidemiology papers that are not only of high impact in terms of introducing novel concepts and opening up new fields of research, but these are papers that also have clear clinical implications that a reader can relate to. These clinical implications include the introduction of novel therapeutic agents or targets, the introduction of new diagnostic tools, or the changing of clinical practice in terms of the way we view, approach, and manage a particular disease.
As a result of these strict definitions, we have had to leave out many key papers that have introduced important electrophysiological concepts. These include the work of Antzelevitch and colleagues in investigating the transmural differences in electrophysiological properties between epicardial and endocardial cells and the discovery of M cells, and the work of Kleber and colleagues on the novel concept of source-sink mismatch, to name but a few.
In order to ensure that we present a good spread of papers that cover a wide range of electrophysiogical concepts and clinical arrhythmias, we have selected a single landmark paper for each of the subcategories listed below, so that these landmark papers cover a range of clinical entities such as atrial fibrillation, ventricular tachycardia, and inherited arrhythmia syndromes, different arrhythmia determinants, such as ionic currents, gap junctional coupling, and intracellular calcium, as well as important epidemiological studies.
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- Foreword
- Preface
- Acknowledgements
- Contributors
- List of abbreviations
- Part I Coronary heart disease
- Chapter 1 Epidemiology, outcomes, and quality of care
- Chapter 2 Lipids and cardiovascular disease
- Chapter 3 Myocardial ischaemia
- Chapter 4 Thrombosis, haemostasis, and platelet biology
- Chapter 5 Medical versus invasive management of coronary heart disease
- Chapter 6 Percutaneous coronary intervention
- Chapter 7 Percutaneous coronary intervention versus coronary artery bypass graft surgery
- Part II Cardiac electrophysiology and heart rhythm disturbances
- Chapter 8 Epidemiology and molecular foundation
- Chapter 9 Atrial fibrillation
- Chapter 10 Interventional electrophysiology
- Chapter 11 Anti-arrhythmic drug therapy
- Part III Heart failure
- Chapter 12 Epidemiology
- Chapter 13 Medical management
- Chapter 14 Cardiac resynchronization therapy
- Chapter 15 Non-ischaemic cardiomyopathy
- Chapter 16 Cardiac failure and transplantation
- Part IV Hypertension
- Chapter 17 Systemic arterial hypertension
- Chapter 18 Pulmonary arterial hypertension
- Part V Valvular heart disease
- Chapter 19 Epidemiology and intervention
- Chapter 20 Endocarditis
- Part VI Cardiac imaging
- Chapter 21 Echocardiography
- Chapter 22 Cardiovascular magnetic resonance
- Chapter 23 Cardiac computed tomography
- Part VII Congenital heart disease
- Chapter 24 Congenital heart disease
- Part VIII Obstetric cardiology
- Chapter 25 Obstetric cardiology
- Part IX Cardiac rehabilitation
- Chapter 26 Cardiac rehabilitation
- Index