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Margot Gosney

, Adam Harper

, and Simon Conroy

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date: 10 May 2021

Fever of unknown origin 248

Dr Stacy Todd and Nick J Beeching

HIV in older people 250

Dr Martin Fisher and Dr Louise Pack

Clostridium difficile diarrhoea: a geriatric syndrome 252

Dr Martin Llewelyn

Fever of unknown origin (FUO) was first defined in 1961 by Petersdorf and Beeson as persistent fever greater than 38.3°C (101°F) that evades diagnosis despite more than 3 weeks of investigation, including at least 1 week in hospital. This has been refined to include four different groupings, each requiring different investigative strategies: classical, nosocomial, neutropenic, and HIV-related FUO. FUO in older people tends to be considered under the classical heading, but the presentation, underlying conditions, and subsequent treatment differ considerably from FUO in a younger adult age group, and FUO in the over 65s could be considered a fifth category....

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